Table 4. Markers of complement activation, endothelial injury and coagulation in the Yale School of Medicine cross-sectional cohort.

	Non-IMV (N=23)	IMV (N=26)	p
C5a, pg/mL	263.8 (225.5 – 848)	475.6 (317.9 – 1353.0)	0.017
Factor D, ng/mL	4, 605 (3,721 – 6,187)	6,437 (3,445 – 9,674)	0.09
Ang2, ng/mL	4,077 (2,149 – 7,633)	11,470 (6,711 – 15,103)	<0.0001
Thrombomodulin, ng/mL	2.9 (1.9 – 4.5)	5.0 (3.0 – 8.1)	0.0068
vWF:Ag, %	375.0 (266.0 – 559.0)*	558.5 (409.8 – 685.3)	0.0063

Abbreviations: Ang2: Angiopoietin-2, vWF:Ag: von Willebrand factor antigen. *Samples for measuring vWF:Ag were available in 21 out of 23 patients who did not need IMV. Statistical tests for comparison were done using the Mann-Whitney U test. Values are represented as median (interquartile range).