Table 1.
Baseline Characteristics Stratified by HOUSES Quartile
| Baseline Characteristics | Q1 56 (30.9) | Q2 48 (26.5) | Q3 51 (28.2) | Q4 26 (14.4) | P value |
|---|---|---|---|---|---|
| Recipient-level | |||||
| Age at Transplant (Mean, SD) | 40.9 (16.8) | 49.9 (15.4) | 49.6 (18.3) | 43.67 (16.8) | 0.017a |
| Sex (Female) | 22 (39.3) | 22 (45.8) | 18 (35.3) | 10 (38.5) | 0.76b |
| Race | 0.035c | ||||
| White | 41 (73.2) | 39 (81.3) | 44 (86.3) | 23 (88.5) | |
| Black/African American | 9 (16.1) | 0 | 1 (2.0) | 0 | |
| Asian | 1 (1.8) | 6 (12.5) | 3 (5.9) | 2 (7.7) | |
| American Indian/Alaskan Native | 1 (1.8) | 1 (2.1) | 1 (2.0) | 0 | |
| More than One | 3 (5.36) | 2 (4.17) | 2 (4.0) | 1 (3.85) | |
| Unknown | 1 (1.79) | 0 | 0 | 0 | |
| Education | 0.070b | ||||
| No High School | 2 (3.9) | 2 (4.3) | 4 (7.8) | 0 | |
| High School | 19 (36.5) | 13 (27.7) | 9 (17.7) | 5 (19.2) | |
| Some College | 16 (30.8) | 16 (34.0) | 22 (43.1) | 10 (38.5) | |
| College | 5 (9.6) | 6 (12.8) | 12 (23.5) | 9 (34.6) | |
| Graduate or Higher | 10 (19.2) | 10 (21.3) | 4 (7.8) | 2 (7.7) | |
| BMI (Mean, SD) | 29.24 (14.7) | 27.23 (5.3) | 28.98 (16.0) | 27.09 (6.8) | 0.81a |
| Previous Kidney Transplant | 9 (16.1) | 3 (6.3) | 7 (13.7) | 4 (15.4) | 0.46c |
| Early Rejection | 2 (4.1) | 6 (13.0) | 2 (4.1) | 1 (4.0) | 0.27c |
| Dialysis Duration (months) | 0.005b | ||||
| Preemptive | 10 (17.9) | 21 (43.8) | 25 (49.0) | 12 (46.2) | |
| >0–6 | 8 (14.3) | 5 (10.4) | 12 (23.5) | 8 (30.8) | |
| >6–12 | 11 (19.6) | 7 (14.6) | 3 (5.9) | 3 (11.5) | |
| >12–18 | 5 (8.9) | 2 (4.2) | 2 (3.9) | 0 | |
| >18 | 22 (39.3) | 13 (27.1) | 9 (17.7) | 3 (11.5) | |
| ESRD Etiology | 0.75b | ||||
| Diabetes | 14 (25.0) | 13 (27.1) | 12 (23.5) | 3 (11.5) | |
| Hypertension | 3 (5.4) | 4 (8.3) | 4 (7.8) | 0 | |
| Cystic/Hereditary | 3 (5.4) | 7 (14.6) | 7 (13.7) | 3 (11.5) | |
| Other | 36 (64.3) | 24 (50.0) | 28 (54.9) | 20 (76.9) | |
| HLA Mismatch (Mean, SD) | 3.39 (1.9) | 3.24 (1.9) | 3.25 (1.9) | 2.83 (2.0) | 0.75a |
| Diabetes | 36 (64.3) | 36 (75.0) | 29 (56.9) | 13 (50.0) | 0.13c |
| Hypertension | 56 (100.0) | 47 (26.3) | 50 (98.0) | 26 (100.0) | 0.64b |
| Delayed Graft | 7 (12.5) | 6 (12.5) | 2 (3.9) | 0 | 0.10c |
| Induction | 0.39b | ||||
| Thymoglobulin | 37 (74.0) | 24 (54.6) | 30 (65.2) | 14 (56.0) | |
| Campath | 6 (12.0) | 8 (18.2) | 4 (8.7) | 5 (20.0) | |
| Other | 7 (14.0) | 12 (27.3) | 12 (26.1) | 6 (24.0) | |
| Immunosuppression | 0.84b | ||||
| Tacrolimus-based | 51 (91.1) | 41 (85.4) | 47 (92.2) | 23 (88.5) | |
| Cyclosporine-based | 3 (5.4) | 3 (6.3) | 3 (5.9) | 2 (7.7) | |
| Other | 2 (3.6) | 4 (8.3) | 1 (2.0) | 1 (3.9) | |
| Calcineurin Inhibitor | 53 (94.6) | 45 (93.8) | 49 (96.1) | 25 (96.2) | 0.95b |
| CMV | 0.72b | ||||
| R−/D− | 9 (22.0) | 9 (25.0) | 10 (23.8) | 7 (26.9) | |
| R+/D+ | 15 (36.6) | 14 (38.9) | 11 (26.2) | 7 (26.9) | |
| R+/D− | 10 (24.4) | 7 (19.4) | 11 (26.2) | 10 (38.5) | |
| R−/D+ | 7 (17.1) | 6 (16.8) | 10 (23.8) | 2 (7.7) | |
| Donor-level | |||||
| Type (Deceased) | 28 (50.0) | 22 (45.8) | 15 (29.4) | 3 (11.5) | 0.003b |
| Age (Mean, SD) | 39.09 (15.4) | 37.57 (21.3) | 41.13 (13.4) | 39 (12.9) | 0.95a |
| Relationship to Donor (Unrelated) | 6 (21.4) | 8 (30.8) | 14 (38.9) | 8 (22.2) | .51c |
Q=Quartile
a
ANOVA test
b
Pearson’s Chi-Square test
c
Fisher’s Exact test for comparing association between HOUSES quartiles and each characteristic