Table 3.
Neuronal receptors.
| Protein Uniprot No. |
Extracellular Domain |
N-glycosylation Sites |
Cytoplasmic Domain | Function |
|---|---|---|---|---|
| RET P07949 |
Complex N-glycans | 12 | Tyr-kinase | survival |
| NTRK1, TrkA P04629 |
oligoMan, Sia binds NGF |
13 | Tyr-kinase | proliferation differentiation |
| NTRK2, TrkB Q16620 |
binds BDNF, NGF4 | 11 | Tyr-kinase | neuronal development proliferation |
| NTRK3, TrkC Q16288 |
binds NGF3 | 13 | Tyr-kinase | survival, differentiation |
| NGFR, p75 P08138 |
O-glycans, binds NGF |
1 | protein-protein interaction | circadian rhythm, apoptosis, differentiation, survival |
| GFRα1 P56159 |
binds GDNF | 3 | GPI anchor | |
| GFRα2 O00451 |
binds NRTN binds RET |
4 | GPI anchor | |
| GFRα3 O60609 |
binds RET binds GDNF |
4 | GPI anchor | |
| GFRα4 Q9GZZ7 |
binds RET binds GDNF |
1 | GPI anchor |
OligoMan, oligomannose-type N-glycans; Sia, sialic acid.