Fig. 3:

(a) SYMPHONY treatment with dual flank bladder cancer tumor (Adapted from Ref. 18) Colored orange are tumor cells. After PTT at the primary tumor, tumor cells with GNS are selectively destroyed and subsequently invokes an immune response. Afterwards, the immune response can target the distant right flank tumor. (b) Kaplan-Meier survival curve of mice in SYMPHONY study. The tumor-free mouse in SYMPHONY group was monitored for 3 months and no tumor recurred. A rechallenge was performed after 150 days and no tumor developed (Adapted from Ref. 18) (c) Tumor size for both the primary and distant tumor was also monitored. Note that only the primary tumor received laser treatment, thus indicating the SYMPHONY treatment’s effectiveness in reducing distant tumor sizes despite not having direct thermal treatment (Adapted from Ref. 18).