Fig. 16. (a) Biotin modulator incorporated onto the surface of MIL-88A(Fe). Overlays of optical and confocal fluorescence microscopy images for (b) MIL-88A(Fe)-Biotin and (c) a MIL-88A(Fe) control after incubation with Alexa-Fluor488-functionalised streptavidin. Reprinted (adapted) with permission from ref. 93. Copyright (2015) John Wiley & Sons. (d) Schematic of the click modulation protocol for stepwise defect-loading of drugs and surface modification of UiO-66. Reprinted (adapted) with permission from ref. 95. Copyright (2017) Elsevier.