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. 2020 May 25;11(23):5969–5973. doi: 10.1039/d0sc00142b

Scope of 1,3-dicarbonyl nucleophilesa,b.

graphic file with name d0sc00142b-u3.jpg
a

Reaction conditions: p-quinone methide (0.05 mmol), 1,3-dicarbonyl compound (0.075 mmol), Cu(OTf)2 (10 mol%), ligand (12 mol%), THF (1.0 mL), 18 h.

b

Isolated yield.

c

ee's of minor diastereoisomers.