MIC values of linear battacin analogues, the values for linear battacin lead 2 and the most potent of each series are highlighted (bolded).
Peptide | E. coli | P. aeruginosa | A. calcoaceticus | S. aureus |
---|---|---|---|---|
MIC (μM) | ||||
9 | 128 | >128 | >128 | >128 |
2 | 8 | >128 | 128 | 64 |
12 | 32 | 64 | 64 | 128 |
12a | 32 | >128 | >128 | >128 |
12b | 16 | >128 | >128 | 128 |
12c | 16 | 32 | 32 | 8 |
12d | 16 | 128 | >128 | >128 |
12e | 8 | 64 | 128 | 64 |
12f | 8 | 8 | 32 | 8 |
13 | 32 | 32 | 64 | 64 |
13a | 16 | >128 | >128 | >128 |
13b | 16 | >128 | >128 | 128 |
13c | 8 | 8 | 32 | 8 |
13d | 16 | 64 | 128 | 64 |
13e | 8 | 64 | 64 | 32 |
13f | 8 | 16 | 32 | 8 |
Tetracycline (μg ml−1) | — | 8 | 2 | — |
Ampicillin (μg ml−1) | 2 | — | — | 0.125 |