Substrate scope for the oxidative transformation of aryl alcohols to thioethersa.
| |||||
|---|---|---|---|---|---|
| Substrates | Products | Yield | Substrates | Products | Yield |
|
|
97% |
|
|
79%* |
|
|
95% |
|
|
95% |
|
|
93% |
|
|
63% |
|
|
87% |
|
|
88% |
|
|
22% |
|
|
72%* |
|
|
32% |
|
|
86%* |
|
|
5%* |
|
|
80%* |
|
|
90%* |
|
|
89%* |
|
|
93%* |
|
|
87%* |
|
|
79%* |
|
|
69%* |
Experiments were performed on the 0.2 mmol scale unless otherwise noted. Optimized conditions: 0.2 mmol alcohols, 0.4 mmol diphenyldisulfane, 0.08 mmol CuSO4, 0.04 mmol phen, 0.8 mmol K2CO3, 200 mg 4 Å, 2 mL DMSO, 0.5 MPa O2, 140 °C, 12 h. *24 h. Yield was determined by GC.