Fig. 2. (A) Normalized fluorescence intensities of pTP-TFE (n = 3), pFTAA (n = 3) and ThT (n = 3) in an aggregation assay starting with tau monomers. (B–D) Representative TEM image of tau aggregates 24 h (B), 96 h (C) and 240 h (D) (white bar = 200 nm). (E and F) Binding affinity of pTP-TFE to tau aggregates collected at 96 hours (E) and 240 hours (F) of the aggregation assay.