Fig. 1. Hf-DBP-Fe harnesses tumor hypoxia for cancer treatment via RT-RDT and CDT as well as synergistic combination with CBI. Local injection of Hf-DBP-Fe in MC38 tumors followed by low-dose X-ray irradiation relieves tumor hypoxia by porphyrin-Fe(iii)-mediated H2O2 decomposition to generate O2 for RDT and ˙OH for both CDT and RT. Immunogenic cell death caused by local RT-RDT and CDT synergizes with anti-PD-L1 CBI to lead to systemic antitumor immunity.
