Table1. Characteristics of included randomized trials in the primary analysis comparing EUS needles.
| Author, year | Country | Mean age ± SD | Female n (%) | Location of mass head/uncinate n (%) | EUS needle evaluated | Number of patients or samples included/analyzed | Positive diagnosis n (%) (accuracy) |
| Alatawi et al 2015 28 | France | 68 ± 11.2 | 15 (30) | 38 (76) | 22G FNA Cook | 50 | 45 (90) |
| 67.8 ± 13.1 | 22 (44) | 34 (68) | 22G FNB Cook | 50 | 50 (100) | ||
| Asokkumar et al 2019 29 | Singapore | 63.5 ± 11.4 | 16 (44) | NR | 22G FNA Boston Scientific | 20 | 18 (90) |
| NR | 22G FNB Boston Scientific | 20 | 18 (90) | ||||
| Bang et al 2012 52 | USA | 65.4 ± 11 | 12 (42.9) | 20 (71.4) | 22G FNA Boston Scientific | 28 | 28 (100) |
| 65 ± 15.4 | 13 (46.4) | 20 (71.4) | 22G FNB Cook | 28 | 25 (89) | ||
| Bang et al 2018 51 | USA | 71.3 ± 11 | 22 (44) | 29 (58) | 22G FNB Boston Scientific | 50 | 47 (94) |
| 22G FNB Medtronic | 50 | 49 (98) | |||||
| Bang et al 2020 49 | USA | 71.9 ± 10.6 | 16 (48.5) | 25 (75.8) | 22G FNB Cook | 33 | 28 (85) |
| 67.9 ± 13.8 | 13 (39.4) | 27 (81.8) | 22G FNB Olympus | 33 | 33 (100) | ||
| 69.8 ± 9.9 | 18 (56.3) | 24 (75) | 22G FNB Boston Scientific | 32 | 32 (100) | ||
| 63.8 ± 15.5 | 14 (45.2) | 23 (74.2) | 22G FNB Medtronic | 31 | 31 (100) | ||
| Cheng et al 2018 30 | China | 58.3 ± 12.2 | 51 (40.7) | NR | 22G FNA Cook | 126 | 107 (85) |
| 58.3 ± 11.1 | 45 (36.4) | NR | 22G FNB Cook | 123 | 110 (89) | ||
| Cho et al 2020 61 | Korea | 69 | 23 (51.1) | 24 (53.3) | 20G FNB Cook | 45 | 40 (89) |
| 64 | 17 (39.5) | 23 (53.5) | 25G FNB Cook | 43 | 34 (79) | ||
| Fabbri et al 2011 31 | Italy | 68.2 ± 7.4 | 20 (40) | 42 (84) | 22G FNA Cook | 50 | 43 (86) |
| 25G FNA Cook | 50 | 47 (94) | |||||
| Gimeno-García et al 2014 32 | Canada | 65.6 ± 11.3 | 61 (50.8) | 43 (34.1) | 22G FNA Cook | 78 | 65 (83) |
| 25G FNA Cook | 78 | 70 (90) | |||||
| Hedenstrom et al 2018 53 | Sweden | 67 | 36 (53) | 35 (51) | 22G FNA Boston Scientific | 68 | 53 (78) |
| 22G FNB Cook | 68 | 47 (69) | |||||
| Hucl et al 2013 33 | India | 51.7 ± 13.6 | 32 (46) | 37 (54) | 22G FNA Cook | 69 | 51 (74) |
| 22G FNB Cook | 69 | 59 (86) | |||||
| Igarashi et al 2019 61 | Japan | 74.4 ± 9.0 | 19 (63.3) | 13 (43.3) | 22G FNB Cook | 30 | 24 (80) |
| 21G FNB Hakko | 30 | 22 (73) | |||||
| Kamata et al 2016 68 | Japan | 68 | 53 (50) | NR | 25G FNB Cook | 106 | 84 (79) |
| 67 | 49 (45) | NR | 25G FNA Cook | 108 | 82 (76) | ||
| Karsenti et al 2020 50 | France | Median (IQR): 69 (63–74) |
22 (37) | 32 (53) | 20G FNB Cook | 60 | 40 (67) |
| 22G FNB Boston Scientific | 60 | 52 (87) | |||||
| Laquière et al 2019 34 | France | 73 | 26 (41) | NR | 22G FNA Cook | 63 | 55 (87) |
| 70 | 22 (37) | NR | 19G FNA Boston Scientific | 59 | 41 (69) | ||
| Lee et al 2009 35 | USA | NR | NR | 7 (58) | 22G FNA Cook | 12 | 12 (100) |
| 25G FNA Cook | 12 | 12 (100) | |||||
| Mavrogenis et al 2015 41 | Belgium | Median: 69 | 18 (67) | NR | 22G FNA Cook | 19 | 16 (84) |
| 25G FNB Cook | 19 | 16 (84) | |||||
| Noh et al 2018 58 | Korea | 61.6 ± 10 | 25 (41.7) | 23 (38) | 22G FNA Olympus | 60 | 57 (95) |
| 22G FNB Cook | 60 | 56 (93) | |||||
| Park et al 2016 63 | Korea | 65.8 ± 9.5 | 21 (38) | 28 (50) | 22G FNB Cook | 56 | 34 (61) |
| 25G FNB Cook | 56 | 37 (66) | |||||
| Ramesh et al 2015 54 | USA | 68.1 ± 11 | 19 (38) | 30 (60) | 19G FNA Boston Scientific | 50 | 48 (96) |
| 68.8 ± 11 | 20 (40) | 31 (62) | 25G FNA Boston Scientific | 50 | 46 (92) | ||
| Sakamoto et al 2009 44 | Japan | NR | NR | 12 (50) | 19G FNA Cook | 24 | 13 (54) |
| 22G FNA Cook | 24 | 19 (79) | |||||
| Song et al 2010 48 | Korea | 56.77 ± 12.13 | 26 (43) | 26 (43) | 19G FNA Cook | 60 | 52 (87) |
| 58.63 ± 11.74 | 29 (51) | 29 (51) | 22G FNA Cook | 57 | 45 (79) | ||
| Sterlacci et al 2016 45 | Germany | 68 ± 12 | 27 (48.2) | NR | 22G FNA Cook | 37 | 33 (89) |
| 22G FNB Cook | 34 | 32 (94) | |||||
| Tian et al 2018 59 | China | 61.4 ± 6.9 | 6 (33.3) | 8 (44.4) | 22G FNA Olympus | 18 | 15 (83) |
| 61.2 ± 9.3 | 7 (38.9) | 8 (44.4) | 22G FNB Cook | 18 | 15 (83) | ||
| Vanbiervliet et al 2014 46 | France | 67.1 ± 11.1 | 31 (39) | 50 (62.5) | 22G FNA Cook | 80 | 74 (93) |
| 22G FNB Cook | 80 | 72 (90) | |||||
| Woo et al 2017 64 | Korea | 61.2 ± 12.8 | 41 (40) | 41 (40) | 22G FNB Cook | 103 | 100 (97) |
| 61.3 ± 11.6 | 37 (36) | 48 (47) | 25G FNB Cook | 103 | 94 (91) |