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. 2021 May 19;2021:5591582. doi: 10.1155/2021/5591582

Figure 3.

Figure 3

EZH2 regulated inflammation and glycolysis through HIF-1α. (a, b) qRT-PCR and Western blot were performed to detect the overexpression of HIF-1α in microglia, respectively. ∗P < 0.05 vs oe-NC group. (c) qRT-PCR were used to detect inflammatory factors IL-6, TNF-α, and IL-17 and glycolysis-related gene PKM2, GLUT1, and HK2 expressions. ∗P < 0.05 vs Control group; #P < 0.05 vs oe-HIF-1α group. (d) Western blot detected inflammatory factors IL-6, TNF-α, and IL-17 and glycolysis-related gene PKM2, GLUT1, and HK2 expressions. ∗P < 0.05 vs. Control group; #P < 0.05 vs. oe-HIF-1α group.