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. 2021 May 13;2021:6632623. doi: 10.1155/2021/6632623

Table 2.

In silico studies of alkaloids with potential anti-SARS-CoV-2 activity.

Alkaloid Chemical structure Mechanisms of action Type of study References
(-)-asperlicin C graphic file with name ECAM2021-6632623.tab2.i001.jpg 3CLpro inhibitory, blocking ACE2 Molecular docking [70]
3α,17α-Cinchophylline graphic file with name ECAM2021-6632623.tab2.i002.jpg Cathepsin L inhibitor Molecular docking [72]
10-Hydroxyusambarensine graphic file with name ECAM2021-6632623.tab2.i003.jpg 3CLpro inhibitor Molecular docking [49]
18-Hydroxy-3-epi-alphayohimbine graphic file with name ECAM2021-6632623.tab2.i004.jpg 3CLpro inhibitor Molecular docking [61]
6-Acetonyldihydrochelerythrine graphic file with name ECAM2021-6632623.tab2.i005.jpg RdRp inhibitor Molecular docking [38]
Adlumidine graphic file with name ECAM2021-6632623.tab2.i006.jpg TMPRSS2 inhibitors Molecular docking [72]
Ajmalicine graphic file with name ECAM2021-6632623.tab2.i007.jpg Blocking Nsp15 Molecular docking [74]
Allocryptopine graphic file with name ECAM2021-6632623.tab2.i008.jpg RdRp inhibitor Molecular docking [38]
Alloyohimbine graphic file with name ECAM2021-6632623.tab2.i009.jpg 3CLpro inhibitor Molecular docking [61]
Amaranthin graphic file with name ECAM2021-6632623.tab2.i010.jpg 3CLpro inhibitor Molecular docking [85]
Anisotine graphic file with name ECAM2021-6632623.tab2.i011.jpg Mpro inhibitor Molecular docking [59]
Asparagamine A graphic file with name ECAM2021-6632623.tab2.i012.jpg 3CLpro inhibitor Molecular docking [61]
Berberine graphic file with name ECAM2021-6632623.tab2.i013.jpg 3CLpro inhibitory, blocking ACE2 and Nsp15 Molecular docking [10, 39, 74]
Cadambine graphic file with name ECAM2021-6632623.tab2.i014.jpg 3CLpro inhibitory Molecular docking [86]
Caffeine graphic file with name ECAM2021-6632623.tab2.i015.jpg Blocking ACE2 Molecular docking [83]
Chrysopentamine graphic file with name ECAM2021-6632623.tab2.i016.jpg 3CLpro inhibitor Molecular docking [49]
Crambescidin 786 graphic file with name ECAM2021-6632623.tab2.i017.jpg Blocking Nsp 10 Molecular docking [82]
Crambescidin 826 graphic file with name ECAM2021-6632623.tab2.i018.jpg Blocking the N proteins Molecular docking [82]
Cryptomisrine graphic file with name ECAM2021-6632623.tab2.i019.jpg Mpro and RdRp inhibitor Molecular docking [50]
Cryptoquindoline graphic file with name ECAM2021-6632623.tab2.i020.jpg Mpro and RdRp inhibitor Molecular docking [49, 50]
Cryptospirolepine graphic file with name ECAM2021-6632623.tab2.i021.jpg Mpro and RdRp inhibitor Molecular docking [49, 50]
Dihydroergotamine graphic file with name ECAM2021-6632623.tab2.i022.jpg 3CLpro inhibitor Molecular docking [63]
Epiisopiloturine graphic file with name ECAM2021-6632623.tab2.i023.jpg Mpro inhibitor Molecular docking [90]
Ergometrine graphic file with name ECAM2021-6632623.tab2.i024.jpg Mpro inhibitor Molecular docking [65]
Ergotamine graphic file with name ECAM2021-6632623.tab2.i025.jpg 3CLpro inhibitor Molecular docking [63]
Fumigatoside E graphic file with name ECAM2021-6632623.tab2.i026.jpg Blocking ACE2 Molecular docking [79]
Indican graphic file with name ECAM2021-6632623.tab2.i027.jpg Mpro inhibitor Molecular docking [40]
Indigo graphic file with name ECAM2021-6632623.tab2.i028.jpg Mpro inhibitor Molecular docking [40]
Indirubin graphic file with name ECAM2021-6632623.tab2.i029.jpg Mpro inhibitor Molecular docking [40]
Nicotine graphic file with name ECAM2021-6632623.tab2.i030.jpg Blocking ACE2 Molecular docking [83]
Norquinadoline A graphic file with name ECAM2021-6632623.tab2.i031.jpg Blocking ACE2 and PLpro inhibitor Molecular docking [80, 81]
Noscapine graphic file with name ECAM2021-6632623.tab2.i032.jpg Mpro inhibitor Molecular docking [77]
Noscapine 23B graphic file with name ECAM2021-6632623.tab2.i033.jpg Mpro inhibitor Molecular docking [78]
Oriciacridone F graphic file with name ECAM2021-6632623.tab2.i034.jpg 3CLpro inhibitory, blocking ACE2 Molecular docking [70]
Oxoturkiyenine graphic file with name ECAM2021-6632623.tab2.i035.jpg Cathepsin L inhibitor Molecular docking [72]
Palmatine graphic file with name ECAM2021-6632623.tab2.i036.jpg 3CLpro inhibitor Molecular docking [66]
Papaverine graphic file with name ECAM2021-6632623.tab2.i037.jpg Mpro inhibitor Molecular docking [65]
Piperine graphic file with name ECAM2021-6632623.tab2.i038.jpg ACE2 blocker Molecular docking [39]
Protopine graphic file with name ECAM2021-6632623.tab2.i039.jpg RdRp inhibitor Molecular docking [38]
Pseudojervine graphic file with name ECAM2021-6632623.tab2.i040.jpg ACE2 blocker Molecular docking [84]
Qingdainone graphic file with name ECAM2021-6632623.tab2.i041.jpg Inhibitors of TMPRSS2 Molecular docking [72]
Reserpine graphic file with name ECAM2021-6632623.tab2.i042.jpg Blocking the Nsp15 Molecular docking [74]
Sanguinarine graphic file with name ECAM2021-6632623.tab2.i043.jpg 3CLpro inhibitor Molecular docking [66]
Solanidine graphic file with name ECAM2021-6632623.tab2.i044.jpg Blocking the S proteins, Mpro inhibitor Molecular docking [58]
Sophaline D graphic file with name ECAM2021-6632623.tab2.i045.jpg Mpro inhibitor Molecular docking [45]
Sophoridine graphic file with name ECAM2021-6632623.tab2.i046.jpg Mpro inhibitor Molecular docking [62]
Speciophylline graphic file with name ECAM2021-6632623.tab2.i047.jpg 3CLpro inhibitor Molecular docking [86]
Tabersonine graphic file with name ECAM2021-6632623.tab2.i048.jpg 3CLpro inhibitor Molecular docking [66]
Taspine graphic file with name ECAM2021-6632623.tab2.i049.jpg Blocking Nsp15 Molecular docking [74]
Tetrahydropalmatine graphic file with name ECAM2021-6632623.tab2.i050.jpg 3CLpro inhibitor Molecular docking [10]
Thalimonine graphic file with name ECAM2021-6632623.tab2.i051.jpg Mpro inhibitor Molecular docking [45]
Thebaine graphic file with name ECAM2021-6632623.tab2.i052.jpg ACE2 blocker Molecular docking [39]
Tryptanthrine graphic file with name ECAM2021-6632623.tab2.i053.jpg Mpro inhibitor Molecular docking [40]
Vincapusine graphic file with name ECAM2021-6632623.tab2.i054.jpg 3CLpro inhibitor Molecular docking [61]

3CLpro: 3-chymotrypsin-like protease, ACE2: angiotensin-converting enzyme 2, E proteins: envelope proteins, Mpro: main proteases, NI: not identified, N proteins: nucleocapsid proteins, Nsp15: nonstructural proteins, RdRp: RNA-dependent RNA polymerase, S proteins: spike proteins, TMPRSS2: transmembrane protease serine 2.