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. 2021 Jun 1;131(11):e147276. doi: 10.1172/JCI147276

Figure 1. Tumor innervation.

Figure 1

Local sympathetic, parasympathetic, and sensory nerves act on incipient cancer cells and the microenvironment to regulate proliferation and enhance metastasis. As tumors progress, new axons are recruited to the tumor microenvironment to further potentiate growth, via exosomes and other mechanisms. Tumor-nerve interactions are tissue specific; thus, interactions depicted are representative of observations in several cancer types.