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. 2021 Jun 1;131(11):e141965. doi: 10.1172/JCI141965

Figure 3. Schematic of hHBV-SIGLEC-3 interaction.

Figure 3

Human SIGLEC-3 interacts with Asn-146 sialoglycans (Neu5Ac(α2-6)-Gal(β1-4)-GlcNAc(β1-2)-Man) located on the small HBsAg. Our data demonstrated that 1 SIGLEC monomer binds to 2 terminal sialic acids on neighboring Asn-146 sialoglycans, thus allowing multiple-valence binding between HBV virion and myeloid cells, cross-linking SIGLEC-3, and triggering downstream signaling. Based on computer modeling (RCSB Protein Data Bank number 5J0B), the S124TKYSYK130 of human SIGLEC-3 is responsible for interaction with terminal sialic acids on Asn-146 sialoglycans.