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. 2021 Jun 1;131(11):e137689. doi: 10.1172/JCI137689

Figure 2. Cardiac CSN6 loss accelerated desmosomal protein dissolution in vivo.

Figure 2

(A and C) Protein blot analyses (A) and quantification of protein expression levels (C) in total protein extracts from Csn6-iKO and control hearts at 2 weeks after tamoxifen injection (n = 5 per group). (B and D) Protein blot analyses (B) and quantification of protein expression levels (D) in total protein extracts from Csn6-iKO and control hearts at 6 weeks after tamoxifen injection (n = 3 per group). FA, fascia adherens; GJ, gap junction. The expression levels of proteins were normalized to the loading control GAPDH. Data are represented as mean ± SEM; 2-way ANOVA with Šidák’s multiple comparison test. **P < 0.01; ***P < 0.001.