Figure 6. CsA inhibits antigen-induced LFA-1/ICAM1–mediated T/DC adhesion via its affect on TCR signaling.

AND or P14 T cells of the indicated genotypes were cultured with antigen-pulsed DCEK or DCEK-D^b cells, respectively, in the presence or absence of CsA for 30 minutes. The binding of WT T cells was considered to be 100%, and the relative number of AND (A) or P14 (B) T cells bound to APCs is shown. Data are shown as the mean ± SEM of 3 or 4 independent experiments. *P < 0.05, ***P < 0.0001.