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. 2021 Jun 1;131(11):e144108. doi: 10.1172/JCI144108

Figure 1. Ablation of Lats1/2 in epithelia of adult kidneys leads to sarcomatoid tumors and TCC.

Figure 1

H&E-stained sections of control kidney (A, C, D, K, and M) or KspCreERT2 Lats-KO kidney (B, E–G, I, L, and N) or lung (H and J) collected 7 weeks (A–F; n = 3 for control and mutant) or 4 months (G–J; n = 4) after the first treatment with high-dose (B, E, and F) or low-dose (G–J) tamoxifen. C–D, E–F, I, and J are high-magnification images of A, B, G, and H, respectively. C and E were taken in the cortex, while D and F are images of the papillae. (K–N) H&E-stained sections of control (K and M) or KspCreERT2 Lats1/2c/c (L and N) kidneys 7 weeks after tamoxifen. Arrows indicate control (M) or mutant (N) ureteric epithelia. Box in K corresponds to M, and box in L corresponds to N. Scale bars: (A, B, G, and H) 900 μm, (C–F, I, J, M, N) 100 μm, (K and L) 2 mm.