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. 2021 Jun 1;131(11):e146987. doi: 10.1172/JCI146987

Figure 1. CAF ontogeny in mouse and human liver metastasis.

Figure 1

(A) Tumor images and their macroscopic fluorescence of LratCre-TdTom and collagen1a1-GFP; confocal microscopy of LratCre-TdTom, collagen1a1-GFP (Col-GFP), Sirius red, and αSMA IHC in Pan02, CMT93, EO771, and B16F10 liver metastasis. Scale bars: 100 μm. (B) Quantification of data in A. Data are shown as the mean ± SEM; n = 3–9 mice/cell line. (C) Representative IHC and quantifications of αSMA in human CRC liver metastasis (n = 100). NT, nontumor; Tu, tumor. Scale bars: 100 μm. Data are shown as the mean ± SEM; paired t test.