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. 2021 Jun 1;131(11):e146987. doi: 10.1172/JCI146987

Figure 10. myCAF-enriched HA promotes tumor growth in vivo.

Figure 10

(A) UMAPs and gene signatures of myCAF and Has2 in Pan02 and CMT93 (n = 1 each). (B) Efficient reduction of HA shown by IHC in Has2ΔHSC mice compared with Has2fl/fl littermates (NL, normal liver; NT, nontumor; Tu, tumor). (C) Representative IHC and quantification of HA staining in human CRC liver metastasis with matched nontumor tissue (n = 100). Scale bars: 100 μm. Statistics were done using Paired t test. (D) Representative macroscopic and IHC images of liver and liver-to-body weight ratio (LBR) and tumor area quantifications (n = 7–8 per group each). Scale bars: 1 cm. Statistics were done using 2-tailed unpaired t test or Mann Whitney U test dependent on data distribution (B and D) and Wilcoxon’s matched-pairs signed-rank test (C). Data are shown as the mean ± SEM.