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. 2021 Jun 1;131(11):e146987. doi: 10.1172/JCI146987

Figure 2. CAF subpopulations in mouse and human liver metastasis.

Figure 2

(A) UMAPs of scRNA-Seq of murine PDAC and CRC liver metastasis (n = 1 each) and human CRC metastasis (n = 6), displaying HSC and PF as a percentage of panCAF; murine HSC markers Lrat, Lum, and Pdgfrb; murine PF marker Msln, Upk1b, and Upk3b; human HSC markers PDGFRB, GEM, and FRZB; and human PF markers MSLN, UPK1B, and UPK3B. (B) UMAPs showing percentages and markers of myCAF, iCAF, and mesCAF subpopulations for murine PDAC models Pan02 and KPCY (n = 1 each), murine CRC model CMT93 (n = 1) and human CRC liver metastasis (n = 6).