Table 1.
Demographic and laboratory parameters of the study cohort
| Variables | Controls (n=17) |
Alcohol use disorder (n=36) |
Alcoholic hepatitis (n=89) |
P Value |
|---|---|---|---|---|
| Sex (% male), n (%), n=141 | 13 (76.5) | 29 (80.6) | 60 (67.4) | 0.370 |
| Age (years), n=141 | 39.0 (27.0–71.0) | 42.0 (27.0–67.0) | 51.3 (30.1–74.8) | <0.001* |
| BMI (kg/m2), n=128 | 22.8 (18.8–29.6) | 23.6 (17.9–31.4) | 27.4 (16.3–48.3) | <0.001* |
| Creatinine (mg/dL), n=124 | 0.8 (0.5–1.3) | 0.8 (0.3–8.1) | 0.635 | |
| Bilirubin (mg/dL), n=124 | 0.5 (0.2–1.5) | 15.8 (2.5–41.1) | <0.001 | |
| AST (IU/L), n=124 | 43.0 (15.0–283.0) | 130.0 (41.0–394.0) | <0.001 | |
| ALT (IU/L), n=124 | 37.0 (9.0–184.0) | 44.0 (15.0–216.0) | 0.148 | |
| Albumin (g/dL), n=113 | 4.5 (2.2–5.2) | 2.4 (1.3–3.9) | <0.001 | |
| INR, n=119 | 0.9 (0.8–1.3) | 1.9 (1.0–4.4) | <0.001 | |
| GGT (IU/L), n=76 | 42.0 (4.0–1131.0) | 166.5 (33.0–3632.0) | <0.001 | |
| Platelet count (109/L), n=118 | 222.0 (80.0–434.0) | 124.0 (13.0–447.0) | <0.001 | |
| FIB-4, n=118 | 1.4 (0.4–9.1) | 8.0 (1.4–79.7) | <0.001 | |
| FIB-4 > 3.25 (F3-F4), n (%) | 5 (16.1) | 78 (90.1) | <0.001 |
Post-hoc P values for age: AH vs AUD, P=0.003; AH vs controls, P=0.008; AUD vs controls, P=0.859. Post-hoc P values for BMI: AH vs AUD, P=0.001; AH vs controls, P=0.025; AUD vs controls, P=0.999.
Values presented are median with range in parentheses for continuous variables or number and percentage in parentheses for categorical variables. Percentages were calculated based on the actual number of patients in each group, when data were available. The number of subjects for which data were available is indicated in the first column.
AH, alcoholic hepatitis; AUD, alcohol use disorder; BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; INR, international normalized ratio; GGT, gamma-glutamyl transferase; FIB-4, fibrosis-4 index.