Table 2.

Pooled genotypic effects of SLCO1B1 gene rs4149056 polymorphisms in Caucasian with specific type of statin.

Study	Author	Year	Myopathy					Control					CC vs TT		TC vs TT
			No. of subjects in case	Genotype				No. of subjects in control	Genotype				OR1	95% CI	OR2	95% CI
				TT		TC	CC		TT		TC	CC
Caucasian with statin users
1	Willrich et al. [38]	2018	89	67		21	1	89	57		30	2	0.43	0.04, 4.81	0.60	0.31, 1.15
2	Bakar et al. [39]	2017	125	78		45	2	476	353		112	11	0.82	0.18, 3.79	1.82	1.19, 2.78
3	Mirošević Skvrce et al. [40]	2015	60	34		22	4	90	69		21	0	18.13	0.95, 346.44	2.13	1.03, 4.39
4	Ferrari et al. [41]	2014	33	8		13	12	33	18		13	2	13.50	2.43,74.87	2.25	0.72, 6.99
5	Carr et al. [26]	2013	76	40		30	6	372	260		101	11	3.55	1.24, 10.12	1.93	1.14, 3.27
6	Brunham et al. [42]	2012	25	15		8	2	83	57		20	6	1.27	0.23, 6.92	1.52	0.56, 4.12
7	Donnelly et al. [17]	2011	816	565		227	24	1275	905		348	22	1.75	0.97, 3.15	1.04	0.86, 1.27
8	Linde et al. [44]	2010	27	14		12	1	19	15		4	0	3.21	0.12, 85.20	3.21	0.84, 12.35
9	Voora et al. [45]	2009	97	62		31	4	351	263		84	4	4.24	1.03, 17.43	1.57	0.95, 2.57
10	Link et al. [18]	2008	85	29		35	21	90	70		17	3	16.9	4.68, 61.06	4.97	2.41, 10.24
	Pooled												2.92	(1.59, 5.34)	1.61	(1.20, 2.16)
Caucasian with atorvastatin users
1	Mirošević Skvrce et al. [40]	2015	60	34	22		4	90	69	21		0	18.13	0.95, 346.44	2.13	1.03, 4.39
2	Carr et al. [26]	2013	11	7	4		0	110	86	22		2	2.31	0.10, 52.59	2.23	0.60, 8.32
3	Brunham et al. [42]	2012	10	7	2		1	34	24	7		3	1.14	0.10, 12.78	0.98	0.16, 5.83
	Pooled												3.95	(1.23, 12.63)	1.98	(1.11, 3.52)
Caucasian with simvastatin users
1	Bakar et al. [39]	2017	125	78	45		2	476	353	112		11	0.82	0.18, 3.79	1.82	1.19, 2.78
2	Carr et al. [26]	2013	59	29	25		5	222	147	71		4	6.34	1.60, 25.03	1.78	0.97, 3.27
3	Brunham et al. [42]	2012	12	5	6		1	39	27	10		2	2.70	0.20, 35.75	3.24	0.81, 13.02
4	Donnelly et al. [17]	2011	816	565	227		24	1275	905	348		22	1.75	0.97, 3.15	1.04	0.86, 1.27
5	Link et al. [18]	2008	85	29	35		21	90	70	17		3	16.90	4.68, 61.06	4.97	2.41, 10.24
	Pooled												2.81	(1.17, 6.77)	1.78	(1.15, 2.77)

CI confidence interval, OR odds ratio.