Table 2.

Summary of clinically-relevant statistics of autoantibody-antigen reactivity combinations that are from 100 to 90% specific with ASD diagnosis in the training and validation set (combined data).

Pattern	Training ASD + /subgroup	Validation ASD + /subgroup	ASD/subgroup	Precision	Precision drop	Total ASD % (n = 450)	Fisher’s exact test p value	OR (95% CI)a	OR p value
CRMP1 + GDA	15/15	4/4	19/19	1.00	0.00	4.2	<0.0001	31.04 (1.8678–516.0620)	0.0166
CRMP1 + CRMP2	12/12	4/4	16/16	1.00	0.00	3.6	0.0001	26.08 (1.5596–436.4170)	0.0233
NSE + STIP1	8/8	6/6	14/14	1.00	0.00	3.1	0.0005	22.82 (1.3565–383.9379)	0.0299
CRMP2 + STIP1	6/6	3/3	9/9	1.00	0.00	2	0.0064	14.78 (0.8573–254.8841)	0.0637
LDHA + YBOX	1/1	5/5	6/6	1.00	0.00	1.3	0.0393	10.04 (0.5640–178.9532)	0.1164
LDHB + YBOX	2/2	4/4	6/6	1.00	0.00	1.3	0.0393	10.04 (0.5640–178.9532)	0.1164
GDA + YBOX	5/5	1/1	6/6	1.00	0.00	1.3	0.0393	10.04 (0.5640–178.9532)	0.1164
STIP1 + YBOX	4/5	7/7	11/12	0.92	0.08	2.4	0.0161	8.56 (1.1010–66.7020)	0.0402
CRMP1 + STIP1	15/17	3/3	18/20	0.90	0.10	4	0.0022	7.10 (1.6371–30.8292)	0.0088

Fisher’s exact (two sided) was used to evaluate the association of the patterns with ASD diagnosis and p values >0.05 were bolded and considered significant. The italic values represent significant combinations that are not 100% ASD-specific, but are statistically significant and have a strong correlation with the ASD group.

^a A 0.5 continuity correction was applied to OR calculations for observations with zero cell counts. The correction was applied to all OR calculations in this table, except the last two patterns (STIP1+YBOX and CRMP1+STIP1).

ASD autism spectrum disorders, OR odds ratio, CI confidence interval, CRMP1 and CRMP2 collapsin response mediator proteins 1 and 2, GDA guanine deaminase, NSE neuron-specific enolase, LDHA-B lactate dehydrogenase A and B, STIP1 stress-induced phosphoprotein 1, and YBOX Y-box binding protein 1.