Table 1.
Significant QTLs for fat mass and lean mass gain during feeding trial and for serum HDL cholesterol concentration after feeding trial.
| Phenotype | Model | Chr | Left marker (Mb) | Top marker (Mb) | Right marker (Mb) | LOD (−log10(P value))ξ | Effect of B6/FVB allelesξ | Effect of FVB/FVB allelesξ | Variance explained (%)ξ |
|---|---|---|---|---|---|---|---|---|---|
| Fat mass gain (during feeding trial) (g) |
Combined (both sexes, both diets) (y ~ sex * diet + marker) |
1 | 180.2 | 191.6 | 194.4 | 4.02b | 1.44 | 2.32 | 3.44 |
|
Combined (both sexes, both diets) (y ~ sex * diet + marker) |
5 | 66.1 | 73.7 | 76.6 | 7.28a | −1.95 | −2.78 | 6.29 | |
|
Combined (both sexes, both diets) (y ~ sex * diet + marker) |
7 | 36.6 | 40.5 | 44.5 | 4.02b | 0.23 | −1.70 | 3.43 | |
| Lean mass gain (during feeding trial) (g) |
Combined (both sexes, both diets) (y ~ sex * diet + marker) |
5 | 66.1 | 73.7 | 76.6 | 4.94a | −0.78 | −1.62 | 3.34 |
| Serum HDL concentration (after feeding trial) (ng/mL) |
Combined (both sexes, both diets) (y ~ sex * diet + marker) |
1 | 160.6 | 168.6 | 176.1 | 11.94a | 26.88 | 48.01 | 9.93 |
ξLOD scores, allele effects, and variance explained are provided for the top marker in each confidence interval. Effects of the B6/FVB and FVB/FVB alleles are given relative to B6/B6 alleles at this location.
aGenome-wide significance threshold of high significance (P < 0.01) based on 10,000 permutations.
bGenome-wide significance threshold of significance (P < 0.05) based on 10,000 permutations.