Table 2.
Candidate genes in QTL confidence intervals for Fmg1 and Fmg2 were annotated with metabolically relevant KEGG pathways.
Phenotype | Model | QTL | KEGG pathway | Gene symbol (MGI) |
---|---|---|---|---|
Fat mass gain (during feeding trial) (g) |
Combined (both sexes, both diets) (y ~ sex * diet + marker) |
Fmgq1 | Steroid hormone biosynthesis (mmu00140) | Hsd11b1 |
Bile secretion (mmu04976) | Ephx1 | |||
Aldosterone synthesis and secretion (mmu04925) | Camk1g | |||
AMPK signaling pathway (mmu04152) | Ppp2r5a | |||
Combined (both sexes, both diets) (y ~ sex * diet + marker) |
Fmgq2 | Steroid hormone biosynthesis (mmu00140) | Srd5a3 | |
Nonalcoholic fatty liver disease (mmu04932) | Cox7b2 |