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. 2021 Mar 15;45(6):1284–1297. doi: 10.1038/s41366-021-00785-7

Table 2.

Candidate genes in QTL confidence intervals for Fmg1 and Fmg2 were annotated with metabolically relevant KEGG pathways.

Phenotype Model QTL KEGG pathway Gene symbol (MGI)
Fat mass gain (during feeding trial) (g)

Combined (both sexes, both diets)

(y ~ sex * diet + marker)

Fmgq1 Steroid hormone biosynthesis (mmu00140) Hsd11b1
Bile secretion (mmu04976) Ephx1
Aldosterone synthesis and secretion (mmu04925) Camk1g
AMPK signaling pathway (mmu04152) Ppp2r5a

Combined (both sexes, both diets)

(y ~ sex * diet + marker)

Fmgq2 Steroid hormone biosynthesis (mmu00140) Srd5a3
Nonalcoholic fatty liver disease (mmu04932) Cox7b2