Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 14;26(5):1589–1605. doi: 10.1038/s41380-020-0669-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Functional annotation analysis shows that top upregulated genes in ASD NPC are enriched (red) within Gene Ontology (GO) terms and canonical pathways related to ribosome biogenesis, translation regulation and mitochondrion function. b Top ranked upregulated genes in ASD neurons (red) are enriched within GO terms and pathways related to synaptic signaling, neurotransmitter release and dendrite extension. A full description of the functional annotation analysis is available in Supplementary Tables 6 and 7. c Illustrative images of ASD neurons co-cultured with non-GFP neurons from the same individual or non-GFP neurons from a control, and control neurons co-culture with non-GFP neurons from the same individual or from an ASD individual. d Box plots showing the quantification of soma size, neurites per cell, number of ramifications per cell and neurite length for all these conditions. NMP: non-mixed patient (n = 3 clones); MP: mixed patient (n = 3 clones); NMC: non-mixed control (n = 5 clones); MC: mixed control (n = 5 clones). At least eight photos per individual per condition were analyzed.