Fig. 3.

Genetic correlation and pTDT analysis of the three primary phenotypes and autism. a This figure provides the results of the genetic correlation analyses between the GWAS for autism and the GWAS for the three primary phenotypes. The dot provides the estimate (genetic correlation), and the lines represent the 95% confidence intervals. The P-values are indicated on top of each line. b This figure provides the results of the pTDT analyses. The y-axis provides the mean pTDT deviation in standard deviations of the mid-parent polygenic scores. Red dot and lines represent the estimate and the 95% CI respectively for the proband (autistic individuals), and the blue dot and lines represent the estimate and the 95% CI respectively for the non-autistic sibling control