Table 1.

Effect of PGS for autism across the three primary phenotypes

β	SE	Z	P	P-threshold	R2	Phenotype
3.11E−02	2.88E−03	10.784	<2.2E−16	1	0.0958	Childhood trauma
3.11E−02	2.88E−03	10.769	<2.2E−16	0.75	0.0955	Childhood trauma
3.07E−02	2.88E−03	1.06E+01	<2.2E−16	0.5	0.0932	Childhood trauma
3.06E−02	2.88E−03	1.06E+01	<2.2E−16	0.25	0.0926	Childhood trauma
2.82E−02	2.88E−03	9.79E+00	<2.2E−16	0.1	0.0787	Childhood trauma
2.23E−02	2.88E−03	7.72E+00	1.22E−14	0.01	0.0486	Childhood trauma
1.24E−02	2.88E−03	4.287	1.82E−05	0.001	0.0144	Childhood trauma
3.28E−02	2.86E−03	1.14E+01	<2.2E−16	1	0.106	Self-harm ideation
3.31E−02	2.86E−03	1.16E+01	<2.2E−16	0.75	0.108	Self-harm ideation
3.28E−02	2.86E−03	1.15E+01	<2.2E−16	0.5	0.107	Self-harm ideation
3.12E−02	2.86E−03	1.09E+01	<2.2E−16	0.25	0.096	Self-harm ideation
2.98E−02	2.86E−03	1.04E+01	<2.2E−16	0.1	0.088	Self-harm ideation
2.58E−02	2.86E−03	9.01E+00	<2.2E−16	0.01	0.066	Self-harm ideation
1.53E−02	2.86E−03	5.32E+00	1.00E−07	0.001	0.023	Self-harm ideation
3.61E−02	2.86E−03	1.26E+01	<2E−16	1	0.129	Self-harm score
3.63E−02	2.86E−03	1.27E+01	<2E−16	0.75	0.13	Self-harm score
3.61E−02	2.86E−03	1.26E+01	<2E−16	0.5	0.129	Self-harm score
3.48E−02	2.86E−03	1.21E+01	<2E−16	0.25	0.12	Self-harm score
3.31E−02	2.86E−03	1.16E+01	<2E−16	0.1	0.108	Self-harm score
2.77E−02	2.86E−03	9.66E+00	<2E−16	0.01	0.075	Self-harm score
1.74E−02	2.86E−03	6.08E+00	1.22E−09	0.001	0.029	Self-harm score

This table provides the result of the polygenic score analyses for the three primary phenotypes at seven different P-value thresholds. For each analysis, we report the regression coefficient (β) and the accompanying standard errors (SE), Z-score (Z) and P-value of the Z-score (P). Variance explained (R²) is provided in percentages