Table 2.
Effect of PGS on individual phenotypic items
| Item | β | SE | Z | P | P-threshold | R2 (%) | Category |
|---|---|---|---|---|---|---|---|
| Felt loved as child | 3.07E−02 | 2.89E−03 | 10.60 | <2.2E−16 | 1 | 0.092 | Childhood trauma |
| Sexually molested as a child | 1.12E−02 | 2.88E−03 | 3.89 | 9.85E-05 | 1 | 0.01 | Childhood trauma |
| Physically abused as a child | 2.53E−02 | 2.88E−03 | 8.79 | <2.2E−16 | 1 | 0.063 | Childhood trauma |
| Felt hated as a child | 2.68E−02 | 2.87E−03 | 9.33 | <2.2E−16 | 1 | 0.07 | Childhood trauma |
| Taken to the doctor as a child | 1.78E−03 | 2.88E−03 | 0.61 | 0.53 | 1 | 0.0004 | Childhood trauma |
| Ever thought life not worth living | 3.27E−02 | 2.86E−03 | 11.43 | <2.2E−16 | 0.75 | 0.168 | SSBI |
| Ever contemplated self-harm | 3.10E−02 | 2.86E−03 | 10.85 | <2.2E−16 | 0.75 | 0.154 | SSBI |
| Ever attempted self-harm | 2.63E−02 | 2.88E−03 | 9.12 | <2.2E−16 | 0.75 | 0.107 | SSBI |
| Recent thoughts of suicide and self-harm | 7.87E−03 | 2.90E−03 | 2.71 | 0.00655 | 0.75 | 0.01 | SSBI |
This table provides the result of the polygenic score analyses for the individual items at specific P-value thresholds. For each analysis we report the regression coefficient (β) and the accompanying standard errors (SE), Z-score (Z) and P-value of the Z-score (P-value). Variance explained (R2) is provided in percentages. Please note, the variance explained for SSBI items is measured using Nagelkerke’s pseudo R2 given that these were binary phenotypes