Table 2.

Associations of PRS-Khera with BMI, obesity, and waist circumference in IDEFICS/I.Family.

(A) BMI
	BMI			Obesity
Scale of PRS	Est., 95% CI	p value	R²	OR, 95% CI	p value	AUC
Continuous	0.33 [0.30, 0.37]	7.9e − 81	0.108	2.33 [2.01, 2.70]	2.0e − 29	0.736
Top decile	0.61 [0.49, 0.73]	5.4e − 24	0.036	3.63 [2.57, 5.14]	2.7e − 13	0.598

(B) Waist circumference
	Waist circumference			Waist top quartile
Scale of PRS	Est., 95% CI	p value	R²	OR, 95% CI	p value	AUC
Continuous	0.36 [0.32, 0.40]	1.8e − 71	0.088	1.97 [1.78, 2.17]	1.5e − 40	0.683
Top decile	0.69 [0.55, 0.82]	8.8e − 24	0.032	3.09 [2.37, 4.03]	6.1e − 17	0.569

Associations adjusted for region of residence, sex, age, parental education, fruit and vegetable score. Z scores for BMI and waist circumference were calculated according to refs. [27, 28]. Obesity was defined according to the extended IOTF criteria [27].