Fig. 6. Lipid metabolism is involved in the pathogenesis of immune disorders.

Environmental dyslipidemia as well as disturbed cellular lipid metabolism critically impacts the aberrant activation and differentiation of immune cells, leading to enhanced pathogenicity of immune cells that triggers tissue inflammation. As a result, unbalanced lipid metabolism contributes to the development of a wide range of immune disorders including autoimmune diseases, allergies, cancers, and infectious diseases. Targeting lipid metabolic pathways may be effective in ameliorating immune disorders in humans.