Table 2.
Poisson regression with robust standard errors for different infection diseases and antibiotic first prescriptions dispensed; controlled for sex, age (linear), arrhythmia and pre-existing allergies against medications
| Dear Doctor Letter for moxifloxacin (02/2008) | Quarterly trend preintervention period I/2006–IV/2007 vs postintervention period I/2009–IV/2010 | Dear Doctor Letter for levofloxacin (09/2012) | Quarterly trend preintervention period I/2010–IV/2011 vs postintervention period I/2013–IV/2014 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Preintervention period n (%) 2006/2007 |
Postintervention period n (%) 2009/2010 |
RR | 95% CI | p Value | Preintervention period n (%) 2010/2011 |
Postintervention period n (%) 2013/2014 |
RR | 95% CI | p Value | |
| Community-acquired pneumonia (CAP) | ||||||||||
| Total antibiotic prescriptions | 7189 | 8415 | 8256 | 8280 | ||||||
| Moxifloxacin | 2068 (28.77) | 1062 (12.62) | 0.44 | 0.41–0.47 | < 0.001 | 1110 (13.44) | 1190 (14.37) | 1.07 | 0.99–1.15 | 0.091 |
| Levofloxacin | 771 (10.72) | 1365 (16.22) | 1.51 | 1.39–1.64 | < 0.001 | 1391 (16.85) | 963 (11.63) | 0.69 | 0.64–0.74 | < 0.001 |
| Amoxicillin/BLI, sultamicillin | 383 (5.33) | 811 (9.64) | 1.79 | 1.59–2.02 | < 0.001 | 902 (10.93) | 1147 (13.85) | 1.26 | 1.16–1.37 | < 0.001 |
| Cefuroxime | 513 (7.13) | 1279 (15.20) | 2.12 | 1.93–2.34 | < 0.001 | 1392 (16.86) | 1681 (20.30) | 1.21 | 1.13–1.29 | < 0.001 |
| Cefpodoxime | 214 (2.98) | 335 (3.98) | 0.95 | 0.94–0.97 | < 0.001 | 269 (3.26) | 249 (3.01) | 1.38 | 1.19–1.60 | < 0.001 |
| Other antibiotics | 3240 (45.07) | 3563 (42.34) | 0.94 | 0.90–0.98 | 0.001 | 3192 (38.66) | 3050 (36.84) | 0.96 | 0.92–0.99 | 0.025 |
| Acute bacterial sinusitis (ABS) | ||||||||||
| Total antibiotic prescriptions | 14790 | 17146 | 16679 | 14746 | ||||||
| Moxifloxacin | 1225 (8.28) | 501 (2.92) | 0.35 | 0.32–0.39 | < 0.001 | 548 (3.29) | 459 (3.11) | 0.94 | 0.84–1.07 | 0.384 |
| Levofloxacin | 520 (3.52) | 666 (3.88) | 1.10 | 0.98–1.23 | 0.091 | 712 (4.27) | 541 (3.67) | 0.86 | 0.77–0.96 | 0.007 |
| Amoxicillin/BLI, sultamicillin | 285 (1.92) | 348 (2.03) | 1.05 | 0.90–1.23 | 0.505 | 352 (2.11) | 426 (2.89) | 1.37 | 1.19–1.57 | < 0.001 |
| Cefuroxime | 1010 (6.83) | 2982 (17.39) | 2.55 | 2.38–2.73 | < 0.001 | 3419 (20.50) | 4014 (27.22) | 1.33 | 1.28–1.38 | < 0.001 |
| Cefpodoxime | 364 (2.46) | 690 (4.03) | 1.34 | 1.13–1.58 | 0.001 | 643 (3.86) | 545 (3.70) | 0.92 | 0.78–1.09 | 0.332 |
| Other antibiotics | 11386 (76.98) | 11959 (69.75) | 0.91 | 0.89–0.92 | < 0.001 | 11005 (65.98) | 8761 (59.41) | 0.90 | 0.89–0.92 | < 0.001 |
| Acute exacerbation of chronic bronchitis (AECB) | ||||||||||
| Total antibiotic prescriptions | 18036 | 24651 | 23822 | 22124 | ||||||
| Moxifloxacin | 3185 (17.66) | 1883 (7.64) | 0.43 | 0.41–0.45 | < 0.001 | 1910 (8.02) | 1768 (7.99) | 0.99 | 0.93–1.06 | 0.792 |
| Levofloxacin | 1409 (7.81) | 3357 (13.62) | 1.73 | 1.63–1.84 | < 0.001 | 3126 (13.12) | 2126 (9.61) | 0.73 | 0.69–0.77 | < 0.001 |
| Amoxicillin/BLI, sultamicillin | 611 (3.39) | 1471 (5.97) | 1.70 | 1.55–1.87 | < 0.001 | 1517 (6.37) | 1810 (8.18) | 1.26 | 1.18–1.35 | < 0.001 |
| Cefuroxime | 834 (4.62) | 2780 (11.28) | 2.43 | 2.25–2.62 | < 0.001 | 3034 (12.74) | 3827 (17.30) | 1.35 | 1.30–1.42 | < 0.001 |
| Cefpodoxime | 260 (1.44) | 489 (1.98) | 1.64 | 1.44–1.86 | < 0.001 | 436 (1.83) | 452 (2.04) | 0.96 | 0.86–1.07 | 0.443 |
| Other antibiotics | 11737 (65.08) | 14671 (59.51) | 0.92 | 0.91–0.93 | < 0.001 | 13799 (57.92) | 12141 (54.88) | 0.95 | 0.94–0.97 | < 0.001 |
Data source—AOK PLUS Saxony