Table 3.

GEE analysis for developing hypothyroidism based on different obesity phenotype during follow-up in male participants according to age (cutoff of 55 years)

	Unadjusted model		Model 1		Model 2		Model 3
	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value
Male under 55 years old
MHNO	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
MHO	1.79 (1.12–2.88)	0.016	1.76 (1.08–2.86)	0.023	1.74 (1.07–2.83)	0.025	1.69 (1.03–2.76)	0.036
MUNO	1.31 (0.54–3.21)	0.549	1.19 (0.49–2.85)	0.701	1.18 (0.49–2.83)	0.714	1.14 (0.48–2.74)	0.766
MUO	2.11 (1.24–3.57)	0.006	2.06 (1.21–3.51)	0.008	2.05 (1.20–3.50)	0.008	1.95 (1.14–3.35)	0.015
Male over 55 years old
MHNO	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
MHO	1.14 (0.61–2.13)	0.674	1.24 (0.67–2.28)	0.496	1.24 (0.67–2.28)	0.495	1.25 (0.68–2.31)	0.465
MUNO	2.30 (1.18–4.47)	0.014	2.19 (1.12–4.27)	0.022	2.19 (1.12–4.27)	0.022	2.28 (1.16–4.47)	0.017
MUO	1.66 (0.91–3.04)	0.102	1.70 (0.93–3.13)	0.086	1.71 (0.93–3.14)	0.086	1.77 (0.96–3.25)	0.067

Model 1: adjustment for age and follow-up time. Model 2: adjustment for age, follow-up time, and TPO-Ab. Model 3: adjustment for age, follow-up time, TPO-Ab, ALT, Cr, and smoking

MHNO metabolically healthy nonobese, MHO metabolically healthy obese, MUNO metabolically unhealthy nonobese, MUO metabolically unhealthy obese, TPO-Ab thyroid peroxidase antibody, GEE generalized estimating equations, OR odds ratio, CI confidence interval