Table 1.
Studies of intravenous thrombolysis (IVT) in acute ischemic stroke due to isolated cervical internal carotid artery occlusion
| Study | Treatment description | Sample (n) | Definition of favorable outcome | Favorable outcome n (%) | Mortalityn (%) | sICHn (%) | Definition of successful recanalization | Successful recanalization, n (%) |
|---|---|---|---|---|---|---|---|---|
| Endo 1998 | IV urokinase or tPA within 6 h | 12 | mRS 0–2 at 1 month | 0 (0%) | 9 (75%) | 0 (0%) | “successful” (DSA) | 0 (0%) |
| Gliem 2017 | IV tPA (no timing specified) | 10 | mRS 0–2 at 3 months | 3 (30%) | 2 (20%) | 0 (0%) | “successful” (US) | 0 (0%) |
| Paciaroni 2012 | IV tPA within 4.5 h | 253 | mRS 0–2 at 3 months | 73 (28.9%) | 65 (25.7%) | 12 (4.7%) | NA | NA |
| Paciaroni 2015 | IV tPA within 4.5 h | 20 | mRS 0–2 at 3 months | 7 (35%) | 2 (10%) | 1 (5%) | NA | NA |
| Rudolf 1999 | IV tPA within 3 h | 15 | mRS 0–2 at 3 months | 5 (33.3%) | 4 (26.7%) | 0 (0%) | “successful” (US) | 6 (40%) |
| Yeo 2016 | IV tPA within 4.5 h | 100 | mRS ≤ 1 at 3 months | 27 (27%) | 21 (21%) | 12 (12%) | Arterial occlusive lesion grading 2–3 | 54 (54%) |
| Overall | 410 | 115 (28%) | 103 (25.1%) | 25 (6.1%) | 60 (14.6%) |
DSA, digital subtraction angiography; IV, intravenous; mRS, modified Rankin Scale; NA, not available; sICH, symptomatic intracerebral hemorrhage; tPA, tissue plasminogen activator; US, carotid ultrasound assessment