Table 3.
Antibiotic exposure, hospital length of stay, and 30-day readmission
| Variable | Pre-intervention (n = 77) |
Post-intervention (n = 129) |
p value |
|---|---|---|---|
| Total duration of antibiotic therapy, daysa | 14.2 (10.8, 17.8) | 9.5 (7.9, 11.2) | < 0.001 |
| Total duration of effective antibiotic therapy, daysa | 14.2(10.7, 17.1) | 9.3 (7.7, 11.1) | < 0.001 |
| Duration of intravenous antibiotic therapy, daysa | 4.5 (3.2, 7.3) | 3.8 (2.3, 6) | < 0.001 |
| Completed therapy with oral antibiotics, n (%) | 60 (77.9) | 103 (79.8) | 0.74 |
| If completed therapy with oral antibiotics, time to oral therapy, daysa | 3.3 (2.4, 4.5) | 2.5 (1.7, 3.5) | < 0.001 |
| Duration of antipseudomonal beta-lactam, daysa | 2.9 (2, 4.3) | 1.9 (1.3, 3.3) | < 0.001 |
| Duration of outpatient antibiotic therapy, daysa | 10 (7, 12) | 6 (4.5, 7.5) | < 0.001 |
| Overall hospital length of stay, daysb | 7.9 ± 11 | 5.3 ± 3.7 | 0.047 |
| < 3 days, n (%) | 12 (15.6) | 40 (31) | 0.01 |
| ≥ 3 to ≤ 5 days, n (%) | 32 (41.6) | 39 (30.2) | 0.10 |
| > 5 to ≤ 7 days, n (%) | 15 (19.5) | 21 (16.6) | 0.56 |
| > 7 to ≤ 10 days, n (%) | 6 (7.8) | 17 (13.2) | 0.24 |
| > 10 days, n (%) | 12 (15.6) | 12 (9.3) | 0.17 |
| All-cause 30-day readmission, n (%) | 17 (22.1) | 18 (14) | 0.13 |
| Infection-related 30-day readmission, n (%) | 3 (3.9) | 3 (2.3) | 1 |
| Re-infections, n (%)c | 0 (0) | 2 (1.6) | 0.53 |
aMedian (interquartile range)
bMean ± standard deviation
cRecurrence of bacteremia or primary site infection with the same Gram-negative bacillus species within 30 days of initial bloodstream infection
Bold value indicates p values of < 0.05