Table 2.
Logistic regression odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between plasma levels of lipid-adjusted polychlorinated biphenyls and odds of incident breast cancer in CBCS-I (n=1,407).
| Overall |
White |
Black |
||||||
|---|---|---|---|---|---|---|---|---|
| PCBs (μ/g lipid) | Median in controls (μg/g lipid) | n cases / n controls | OR (95% CI)a | n cases / n controls | OR (95% CI)a | n cases / n controls | OR (95% CI)a | PInteractionb |
| PCB74 | 0.87 | |||||||
| ≤0.0108 | 0.00631 | 242/220 | 1.0 | 172/134 | 1.0 | 70/86 | 1.0 | |
| 0.0109–0.0202 | 0.0153 | 235/220 | 1.1 (0.83–1.5) | 142/138 | 0.90 (0.63–1.3) | 93/82 | 1.6 (0.98–2.6) | |
| >0.0202 | 0.0290 | 271/219 | 1.3 (0.95–1.8) | 142/117 | 1.2 (0.80–1.8) | 129/102 | 1.7 (1.0–2.9) | |
| Ln(PCB74) | 1.2 (1.0–1.4) | 1.2 (0.95–1.4) | 1.3 (0.99–1.6) | |||||
| PCB99 | 0.90 | |||||||
| ≤0.00742 | 0.00472 | 245/217 | 1.0 | 190/158 | 1.0 | 55/59 | 1.0 | |
| 0.00743–0.0143 | 0.0106 | 217/217 | 1.1 (0.80–1.4) | 135/132 | 1.0 (0.71–1.4) | 82/85 | 1.2 (0.70–2.0) | |
| >0.0143 | 0.0226 | 279/216 | 1.4 (1.0–1.9) | 126/93 | 1.4 (0.97–2.1) | 153/123 | 1.5 (0.89–2.6) | |
| Ln(PCB99) | 1.2 (1.0–1.4) | 1.2 (0.97–1.4) | 1.3 (1.0–1.7) | |||||
| PCB118 | 0.77 | |||||||
| ≤0.0172 | 0.0115 | 273/216 | 1.0 | 198/154 | 1.0 | 75/62 | 1.0 | |
| 0.0173–0.0315 | 0.0228 | 216/218 | 0.90 (0.68–1.2) | 139/132 | 0.96 (0.67–1.4) | 77/86 | 0.80 (0.48–1.3) | |
| >0.0315 | 0.0476 | 252/216 | 1.1 (0.79–1.5) | 114/97 | 1.2 (0.81–1.9) | 138/119 | 1.0 (0.59–1.7) | |
| Ln(PCB118) | 1.2 (0.99–1.4) | 1.2 (0.95–1.5) | 1.2 (0.93–1.6) | |||||
| PCB138 | 0.32 | |||||||
| ≤0.0402 | 0.0288 | 248/216 | 1.0 | 179/149 | 1.0 | 69/67 | 1.0 | |
| 0.0403–0.0691 | 0.0515 | 244/218 | 1.1 (0.8–1.4) | 171/142 | 1.2 (0.83–1.7) | 73/76 | 0.91 (0.54–1.5) | |
| >0.0691 | 0.0973 | 249/216 | 1.1 (0.78–1.5) | 101/92 | 1.0 (0.67–1.6) | 148/124 | 1.2 (0.70–2.0) | |
| Ln(PCB138) | 1.2 (0.99–1.4) | 1.2 (0.97–1.6) | 1.2 (0.87–1.6) | |||||
| PCB146 | 0.92 | |||||||
| ≤0.00401 | 0.00213 | 253/216 | 1.0 | 192/151 | 1.0 | 61/65 | 1.0 | |
| 0.00402–0.00925 | 0.00616 | 237/216 | 1.1 (0.82–1.5) | 160/143 | 1.1 (0.74–1.5) | 77/73 | 1.2 (0.71–2.1) | |
| >0.00925 | 0.0147 | 251/216 | 1.1 (0.80–1.6) | 99/86 | 1.1 (0.68–1.6) | 152/130 | 1.4 (0.80–2.3) | |
| Ln(PCB146) | 1.1 (0.96–1.3) | 1.1 (0.88–1.4) | 1.3 (0.97–1.6) | |||||
| PCB153 | 0.81 | |||||||
| ≤0.0516 | 0.0372 | 268/216 | 1.0 | 195/149 | 1.0 | 73/68 | 1.0 | |
| 0.0517–0.0832 | 0.0644 | 233/219 | 1.0 (0.75–1.3) | 158/147 | 0.93 (0.66–1.3) | 75/72 | 1.1 (0.67–1.9) | |
| >0.0832 | 0.116 | 240/215 | 0.96 (0.69–1.3) | 98/88 | 0.90 (0.59–1.4) | 142/127 | 1.2 (0.69–2.0) | |
| Ln(PCB153) | 1.0 (0.86–1.3) | 0.97 (0.76–1.3) | 1.3 (0.91–1.8) | |||||
| PCB156 + PCB171c | 0.34 | |||||||
| ≤0.00626 | 0.00230 | 245/220 | 1.0 | 158/136 | 1.0 | 87/84 | 1.0 | |
| 0.00627–0.0154 | 0.0104 | 257/220 | 1.1 (0.86–1.5) | 178/138 | 1.2 (0.84–1.7) | 79/82 | 1.1 (0.65–1.7) | |
| >0.0154 | 0.0234 | 246/219 | 1.1 (0.81–1.5) | 120/115 | 1.1 (0.72–1.7) | 126/104 | 1.3 (0.75–2.1) | |
| Ln(PCB156 + PCB171) | 1.1 (0.94–1.2) | 1.1 (0.93–1.3) | 1.1 (0.87–1.3) | |||||
| PCB170 + PCB190c | 0.92 | |||||||
| ≤0.0145 | 0.00838 | 246/210 | 1.0 | 165/131 | 1.0 | 81/79 | 1.0 | |
| 0.0146–0.0257 | 0.0208 | 253/211 | 1.2 (0.86–1.5) | 170/131 | 1.2 (0.81–1.7) | 83/80 | 1.2 (0.73–2.0) | |
| >0.0257 | 0.0356 | 222/210 | 0.87 (0.64–1.2) | 103/109 | 0.75 (0.50–1.1) | 119/101 | 1.1 (0.68–1.8) | |
| Ln(PCB170 + PCB190) | 0.91 (0.79–1.0) | 0.87 (0.73–1.0) | 0.98 (0.79–1.2) | |||||
| PCB180 | 0.30 | |||||||
| ≤0.0423 | 0.0314 | 260/216 | 1.0 | 187/140 | 1.0 | 73/76 | 1.0 | |
| 0.0424–0.0671 | 0.0531 | 237/216 | 1.0 (0.77–1.4) | 151/134 | 0.98 (0.68–1.4) | 86/82 | 1.2 (0.7–1.9) | |
| >0.0671 | 0.0914 | 242/216 | 0.98 (0.72–1.3) | 112/107 | 0.85 (0.57–1.3) | 130/109 | 1.4 (0.84–2.4) | |
| Ln(PCB180) | 1.1 (0.86–1.3) | 0.92 (0.72–1.2) | 1.4 (1.0–2.0) | |||||
| PCB182 + PCB187b | 0.67 | |||||||
| ≤0.00787 | 0.00279 | 272/219 | 1.0 | 210/159 | 1.0 | 62/60 | 1.0 | |
| 0.00788–0.0177 | 0.0119 | 224/221 | 0.97 (0.73–1.3) | 157/145 | 0.95 (0.67–1.4) | 67/76 | 1.0 (0.58–1.8) | |
| >0.0177 | 0.0267 | 252/219 | 1.1 (0.78–1.6) | 89/85 | 1.0 (0.64–1.6) | 163/134 | 1.4 (0.82–2.5) | |
| Ln(PCB182 + PCB187) | 1.1 (0.95–1.3) | 1.1 (0.89–1.3) | 1.2 (0.94–1.5) | |||||
| PCB194 | 0.83 | |||||||
| ≤0.00700 | 0.00374 | 239/219 | 1.0 | 210/159 | 1.0 | 78/86 | 1.0 | |
| 0.00701–0.0141 | 0.0107 | 252/220 | 1.1 (0.84–1.5) | 157/145 | 1.0 (0.69–1.5) | 81/77 | 1.3 (0.81–2.2) | |
| >0.0141 | 0.0192 | 257/220 | 1.3 (0.91–1.8) | 89/85 | 1.1 (0.72–1.7) | 133/107 | 1.6 (0.96–2.7) | |
| Ln(PCB194) | 1.2 (0.97–1.4) | 1.1 (0.87–1.3) | 1.3 (0.99–1.7) | |||||
| PCB196 + PCB203c | 0.73 | |||||||
| ≤0.00780 | 0.00440 | 264/219 | 1.0 | 186/135 | 1.0 | 78/84 | 1.0 | |
| 0.00781–0.0149 | 0.0112 | 246/220 | 1.0 (0.75–1.4) | 162/151 | 0.80 (0.55–1.2) | 84/69 | 1.7 (0.97–2.8) | |
| >0.0149 | 0.0203 | 238/220 | 1.0 (0.73–1.5) | 108/103 | 1.0 (0.63–1.6) | 130/117 | 1.4 (0.79–2.4) | |
| Ln(PCB196 + PCB203) | 1.1 (0.89–1.3) | 1.0 (0.80–1.3) | 1.2 (0.89–1.6) | |||||
| PCB201 | 0.98 | |||||||
| ≤0.0111 | 0.00559 | 250/219 | 1.0 | 180/140 | 1.0 | 70/79 | 1.0 | |
| 0.0112–0.0210 | 0.0159 | 233/221 | 1.0 (0.75–1.3) | 151/137 | 0.90 (0.63–1.3) | 82/84 | 1.2 (0.71–1.9) | |
| >0.0210 | 0.02963 | 265/219 | 1.2 (0.90–1.7) | 125/112 | 1.1 (0.69–1.6) | 140/107 | 1.7 (1.0–2.8) | |
| Ln(PCB201) | 1.2 (1.0–1.4) | 1.1 (0.93–1.4) | 1.3 (1.0–1.7) | |||||
a
Adjusted for age at diagnosis (continuous in years), age-squared, race (Black vs. White), menopausal status (pre-menopausal vs. post-menopausal), BMI (<25.0, 25.0–29.9, vs. ≥30.0 kg/m2), parity and breastfeeding composite (parity 1–2, never breastfeed; parity 1–2, ever breastfed; parity 3+, never breastfed; parity 3+, ever breastfed; vs. nulliparous), hormone replacement therapy use (ever vs. never), and annual household income (<$15,000, $15,000 – <$30,000, $30,000 – <$50,000, vs. ≥$50,000), as appropriate.
b
P for multiplicative interaction from logistic regression models using continuous natural log-transformed lipid-standardized PCB levels and race.
c
These analytes are quantitated and reported as the sum of their concentrations because they co-elute during GC/MS analysis.