Table 3.
Unadjusted and adjusted rates and relative risks of positive screening rates, invasive procedures, complications, and cancer detection by screening round, NLST
| Baseline Screening | Subsequent Screening | |||||
|---|---|---|---|---|---|---|
| PHC Rate/100 (95% CI) |
No PHC Rate/100 (95% CI) |
Relative Risk (95% CI) |
PHC Rate/100 (95% CI) |
No PHC Rate/100 (95% CI) |
Relative Risk (95% CI) |
|
| Unadjusted Rates | ||||||
| Lung-RADS Positive a | 14.9 (12.9-17.1) |
13.5 (13.1-14.0) |
1.12 (0.94-1.33) |
6.0 (5.0-7.1) |
5.6 (5.4-5.8) |
1.07 (0.88-1.29) |
| Invasive Procedure b | 3.9 (2.9-5.3) |
1.9 (1.7-2.0) |
2.17 (1.58-2.99) |
1.5 (1.1-2.2) |
1.2 (1.1-1.3) |
1.34 (0.93-1.95) |
| Complication c | 1.4 (0.9-2.3) |
0.6 (0.5-0.7) |
2.54 (1.50-4.30) |
0.5 (0.2-0.9) |
0.6 (0.5-0.6) |
0.87 (0.46-1.67) |
| Cancer Detection d | 2.3 (1.6-3.4) |
0.8 (0.7-1.0) |
2.85 (1.88-4.32) |
0.6 (0.5-0.9) |
0.4 (0.4-0.5) |
1.52 (1.13-2.10) |
| Age Adjusted Rates | ||||||
| Lung-RADS Positive a | 13.7 (11.9-15.8) |
13.3 (12.8-13.7) |
1.04 (0.88-1.24) |
5.6 (4.7-6.7) |
5.5 (5.3-5.8) |
1.02 (0.84-1.23) |
| Invasive Procedure b | 3.4 (2.5-4.6) |
1.8 (1.6-1.9) |
1.98 (1.44-2.74) |
1.3 (0.9-1.9) |
1.1 (1.0-1.2) |
1.24 (0.86-1.79) |
| Complication c | 1.1 (0.6-1.8) |
0.5 (0.4-0.6) |
2.21 (1.30-3.76) |
0.4 (0.2-0.7) |
0.5 (0.45-0.6) |
0.78 (0.41-1.50) |
| Cancer Detection d | 1.9 (1.2-2.8) |
0.8 (0.7-0.9) |
2.51 (1.67-3.81) |
0.6 (0.4-0.8) |
0.4 (0.4-0.5) |
1.37 (0.99-1.93) |
a
The number of participants with a positive lung screening exam based on Lung-RADS of 3, 4A, 4B, or 4X per 100 screening examinations.
b
Invasive procedure rate calculated as the number of participants with an invasive procedure per 100 screening examinations.
c
Complication rate calculated as the number of participants with a complication from work-up per 100 screening examinations.
d
Cancer detection rate calculated as the number of true-positive exams within one-year of the screening LDCT per 100 screening examinations.