Table 3.
Serum concentrations of persistent endocrine-disrupting chemical exposure among mothers of the Avon Longitudinal Study of Parents and Children (ALSPAC) during pregnancy (median gestational age at sample collection: 15 weeks) (N=448 mother-daughter dyads).
| Serum concentrations |
||||
|---|---|---|---|---|
| Q1 | Median | Q3 | % <LOD | |
|
Per- and polyfluoroalkyl substances (PFAS) (ng/mL) | ||||
| PFOA | 2.8 | 3.7 | 4.8 | 0.0 |
| PFOS | 15.1 | 19.8 | 24.9 | 0.0 |
| PFHxS | 1.2 | 1.6 | 2.2 | 0.2 |
| PFNA | 0.41 | 0.49 | 0.66 | 0.2 |
| FOSA | <LOD | 0.20 | 0.30 | 30.6 |
| MeFOSAA | 0.26 | 0.35 | 0.65 | 14.5 |
| EtFOSAA | 0.40 | 0.60 | 0.90 | 2.5 |
| PFDA | <LOD | <LOD | <LOD | 97.3 |
|
Polychlorinated biphenyls (PCBs) (ng/g lipid) | ||||
| PCB28 | 3.5 | 5.3 | 8.3 | 8.7 |
| PCB44 | <LOD | 1.9 | 4.0 | 30.4 |
| PCB49 | <LOD | <LOD | 1.9 | 58.3 |
| PCB52 | <LOD | 3.3 | 7.6 | 30.1 |
| PCB66 | <LOD | 1.6 | 2.5 | 30.4 |
| PCB74 | 8.6 | 11.1 | 15.1 | 0.22 |
| PCB87 | <LOD | <LOD | 1.7 | 59.6 |
| PCB99 | 7.0 | 9.4 | 12.1 | 0.9 |
| PCB101 | <LOD | 2.2 | 5.4 | 30.4 |
| PCB105 | 2.0 | 2.9 | 4.0 | 7.4 |
| PCB110 | <LOD | <LOD | 2.8 | 53.6 |
| PCB118 | 10.9 | 14.9 | 20.6 | 0.22 |
| PCB128 | <LOD | <LOD | <LOD | 89.5 |
| PCB138a | 30.4 | 41.5 | 54.0 | 0.2 |
| PCB146 | 4.6 | 6.0 | 8.1 | 2.5 |
| PCB149 | <LOD | <LOD | 1.8 | 60.9 |
| PCB151 | <LOD | <LOD | <LOD | 79.5 |
| PCB153 | 48.3 | 64.5 | 85.8 | 0.0 |
| PCB156 | 4.8 | 6.3 | 8.4 | 1.8 |
| PCB157 | <LOD | 1.3 | 1.9 | 33.9 |
| PCB167 | <LOD | 2.0 | 2.8 | 26.1 |
| PCB170 | 14.5 | 18.9 | 24.9 | 0.0 |
| PCB172 | 1.1 | 1.9 | 2.7 | 23.0 |
| PCB177 | 2.3 | 3.1 | 4.1 | 8.9 |
| PCB178 | 1.8 | 2.7 | 3.7 | 14.3 |
| PCB180 | 33.5 | 45.2 | 60.1 | 0.0 |
| PCB183 | 4.6 | 6.2 | 8.2 | 3.4 |
| PCB187 | 8.6 | 11.3 | 15.2 | 1.1 |
| PCB189 | <LOD | <LOD | 0.7 | 74.3 |
| PCB194 | 5.5 | 7.5 | 10.4 | 3.4 |
| PCB195 | 1.5 | 2.2 | 3.0 | 19.0 |
| PCB196a | 5.7 | 7.7 | 10.5 | 2.0 |
| PCB199 | 3.9 | 5.5 | 7.8 | 2.7 |
| PCB206 | 1.7 | 2.3 | 3.2 | 10.3 |
| PCB209 | <LOD | 1.5 | 2.0 | 27.7 |
|
Organochlorine pesticides (ng/g lipid) | ||||
| HCB | 37.9 | 50.2 | 63.4 | 0.0 |
| β-HCH | 34.6 | 47.1 | 62.4 | 1.8 |
| γ-HCH | <LOD | <LOD | <LOD | 79.0 |
| Oxychlordane | <LOD | <LOD | 4.2 | 71.9 |
| Trans-nonachlor | <LOD | <LOD | 4.6 | 67.0 |
| p,p’-DDE | 193 | 311 | 499 | 0.2 |
| o,p’-DDT | <LOD | <LOD | <LOD | 98.4 |
| p,p’-DDT | 7.7 | 11.0 | 16.2 | 11.4 |
| Mirex | <LOD | <LOD | <LOD | 99.3 |
Abbreviations: Q1, quartile 1; Q3, quartile 3; LOD, limit of detection; ng/mL, nanogram per milliliter; ng/g lipid, nanogram per gram lipid
a
PCB congeners 138 and 158 could not be separated and were quantified as a summed concentration, referred to as PCB138. Similarly, PCB congeners 196 and 203 could not be separated and were quantified as a summed concentration, referred to as PCB196