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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: J Thorac Oncol. 2021 Mar 17;16(6):968–979. doi: 10.1016/j.jtho.2021.02.024

Figure 3. Meta-Analyses of Associations Between Smoking-Related Factors and Second Primary Lung Cancer Across MEC, PLCO, and EPIC.

Figure 3.

Cause-specific proportional hazards models accounting for the competing risk of death from all causes were used to evaluate the risk of second primary lung cancer by (A) smoking per 10 pack-years, (B) smoking per 10 cigarettes per day, and (C) meeting the 2013 USPSTF screening criteria, adjusting for IPLC age at diagnosis, stage, and histology in MEC and PLCO and by IPLC age at diagnosis and histology in EPIC. Abbreviations: MEC Multiethnic Cohort; PLCO Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial; EPIC European Prospective Investigation into Cancer and Nutrition; USPSTF United States Preventive Services Task Force; IPLC initial primary lung cancer; SE standard error; HR hazard ratio; CI confidence interval.