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. Author manuscript; available in PMC: 2021 Sep 8.
Published in final edited form as: Nat Chem Biol. 2021 Mar 8;17(6):665–674. doi: 10.1038/s41589-021-00751-4

Figure 2. Analysis of ferroptosis suppressor clusters.

Figure 2.

a, A cluster of ferroptosis suppressors (green bar in Fig. 1b) contains many known radical scavengers. b, Structures for select compounds found within the cluster in a. c, Effect of select compounds from the cluster in a (black arrows) on cell death in an S. cerevisiae model of ferroptosis. VX-765 and LGK-974 were randomly selected negative control compounds. d, A distinct cluster of ferroptosis suppressors containing known iron chelators. e, Structures for select compounds found within the cluster in d. f, Effect of select compounds from the cluster in d on cell death in an S. cerevisiae model of ferroptosis. TGX-221 and cediranib were randomly selected negative control compounds. Results in c and f are from three independent experiments.