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. Author manuscript; available in PMC: 2021 Sep 8.
Published in final edited form as: Nat Chem Biol. 2021 Mar 8;17(6):665–674. doi: 10.1038/s41589-021-00751-4

Extended Data Fig. 2. Investigating ferroptosis inhibitors.

Extended Data Fig. 2

a, Cell death data extracted from the compendium for erastin treatment. Each dot represents a single modulator compound, tested once at 5 μM, organized together by major target class. Lower nAUC values indicate greater death suppression. MEKi: mitogen activated protein kinase kinase 1/2 inhibitors (n = 14); AdRm: adrenergic receptor modulators (n = 55); ER/PRm: estrogen/progesterone receptor modulators (n = 29); VEGFRi: vascular endothelial growth factor receptor inhibitors (n = 20); K+Cm: potassium channel modulators (n = 19). The vertical dotted line indicates the mean lethality of the control erastin + DMSO conditions. b, Cell death determined by counting SYTOX Green positive (SG+) objects. The experiment was performed twice on different days and data represents mean ± SD.