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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2021 May 2;60(23):13057–13064. doi: 10.1002/anie.202103553

Table 3.

Substrate Scope of the Enantioselective Carboacylation with Cyclic Trisubstituted Olefins.[a]

graphic file with name nihms-1701560-t0005.jpg
[a]

The reaction was carried out on a 0.1 mmol scale of substrate with [Rh(COD)2]NTf2 (5 mol %), (R)-DTBM-segphos (6 mol%) in 1,2-DFB (1 mL) at 130°C for 48 h.

[b]

All yields are isolated yields; the enantiomeric ratio (er) value was determined by chiral HPLC.

[c]

The reaction was carried out on a 1 mmol scale of substrate with [Rh(COD)2]NTf2 (4 mol %), (R)-DTBM-segphos (4.8 mol%) in 1,2-DFB (0.5 mL) at 130°C for 48 h. Ts: p-toluenesulfonyl; Ac: acetate.