Table 1.
Characteristics of CVD risk factors in JHS and associations with sCD14
| Effect estimate of sCD14 | |||||
|---|---|---|---|---|---|
| N | Mean (SD) or N (%) |
Beta | 95% CI | p- value |
|
| sCD14 | 3492 | 1247.7 (315.9) | |||
| Age (Years) | 3492 | 55.6 (12.8) | 2.43 | (1.97, 2.88) | <0.001 |
| Male Sex (versus female) | 3492 | 1319 (37.8%) | −0.24 | (−0.3, −0.19) | <0.001 |
| Body Mass Index (kg/m2) | 3485 | 31.9 (7.3) | −0.01 | (−0.02, −0.01) | <.001 |
| Waist Circumference (cm) | 3485 | 101.2 (16.2) | −0.31 | (−0.75, 0.13) | 0.16 |
| Current Smoker (yes versus no) | 3462 | 459 (13.1%) | 0.31 | (0.25, 0.37) | <0.001 |
| Hypertension Status | 3492 | 2004 (57.4%) | 0.13 | (0.08, 0.18) | <0.001 |
| Systolic Blood Pressure (mmHg) | 3458 | 136 (20) | 0.53 | (−0.03, 1.10) | 0.064 |
| Diastolic Blood Pressure (mmHg) | 3458 | 81 (10) | −0.08 | (−0.36, 0.19) | 0.56 |
| Type 2 Diabetes | 3490 | 807 (23.1%) | 0.27 | (0.22, 0.33) | <0.001 |
| Fasting Plasma Glucose (mg/dL)* | 2591 | 90 (9) | 0.11 | (−0.23, 0.44) | 0.53 |
| Fasting Triglyceride (mg/dL) | 3237 | 108 (82) | 0.07 | (0.04, 0.10) | <0.001 |
| Statin Medication Use | 3459 | 485 (13.9%) | 0.04 | (−0.02, 0.11) | 0.19 |
| Fasting Total Cholesterol (mg/dL) | 3237 | 199 (41) | 0.57 | (−0.96, 2.10) | 0.47 |
| Fasting LDL Cholesterol (mg/dL) | 3204 | 127 (37) | −0.87 | (−2.11, 0.37) | 0.17 |
| Fasting HDL Cholesterol l (mg/dL) | 3236 | 52 (15) | −0.55 | (−1.57, 0.47) | 0.29 |
| C-Reactive Protein (mg/dL) | 3490 | 0.5 (1) | 0.23 | (0.2, 0.26) | <0.001 |
Beta values are reported per SD of sCD14 (316 ng/mL), including for binary measures. Models are adjusted for age and sex (except for age and sex). BMI, triglycerides, and CRP are natural log transformed prior to analysis.
*
Plasma glucose was obtained from fasting blood samples and was assessed only in those without type 2 diabetes.