Table 2:

Cross-sectional associations of sCD14 with subclinical CVD measures in JHS

			Model
			1*		2†		3‡
	N	Mean (SD) or N (%)	Beta (95% CI)	p-value	Beta (95% CI)	p- value	Beta (95% CI)	p-value
Ankle Brachial Index (ABI)	2836	1.2 (0.2)	−0.018 (−0.023, −0.012)	<.001	−0.015 (−0.02, −0.009)	<.001	−0.014 (−0.019, −0.008)	<.001
Carotid intima media thickness (cIMT)	3021	0.7 (0.2)	−0.005 (−0.01, 0.001)	0.11	−0.008 (−0.013, −0.002)	0.01	−0.008 (−0.015, −0.002)	0.01
Left Ventricular Mass Index	2056	36 (9.6)	0.005 (−0.008, 0.019)	0.44	0.004 (−0.01, 0.019)	0.57	0.003 (−0.012, 0.018)	0.73
Coronary Artery Calcium (CAC) Score	1787	157 (489)	0.11 (0.02, 0.21)	0.02	0.02 (−0.07, 0.1)	0.71	−0.01 (−0.121, 0.101)	0.86
Abdominal Aorto-iliac Calcium (AAC) Score	1786	861 (1600)	0.27 (0.05, 0.49)	0.02	0.1 (−0.09, 0.3)	0.30	0.08 (−0.14, 0.3)	0.50
Left Ventricular Hypertrophy (LVH)	2233	150 (4.7%)	0.13 (0.01, 0.24)	0.04	0.09 (−0.04, 0.23)	0.17	0.09 (−0.07, 0.24)	0.28
Any AAC	1936	1173 (37.0%)	0.14 (−0.03, 0.31)	0.11	0.03 (−0.16, 0.21)	0.78	0.01 (−0.19, 0.21)	0.94
Any CAC	1937	845 (26.6%)	0.115 (0.001, 0.229)	0.05	0.02 (−0.08, 0.12)	0.69	0.003 (−0.12, 0.125)	0.97

Beta values and 95% confidence intervals (CIs) are reported per SD increase in sCD14 (316 ng/mL). P-values meeting the Bonferroni-corrected significance threshold of 0.006 are shown in bold.

CIMT, LVMI, CAC and AAC were natural log transformed prior to analysis.

^*Model 1: Adjusted for age and sex

^†Model 2: Model 1 + BMI, blood pressure medications, type 2 diabetes, SBP, total cholesterol, HDL cholesterol, current smoking

^‡Model 3: Model 2 + CRP