Table 3:
Associations of sCD14 with mortality and incident cardiovascular disease events in JHS
| Model | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1* | 2† | 3‡ | |||||||||
| Outcome | Events | N | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value |
| All-Cause Mortality | 716 | 3,171 | 1.27 | (1.19,1.35) | <.001 | 1.23 | (1.16,1.29) | <.001 | 1.19 | (1.13,1.25) | <.001 |
| Coronary Heart Disease | 123 | 2,904 | 1.45 | (1.29,1.63) | <.001 | 1.32 | (1.18,1.48) | <.001 | 1.29 | (1.16,1.44) | <.001 |
| Heart Failure | 227 | 2,755 | 1.25 | (1.15,1.36) | <.001 | 1.20 | (1.11,1.3) | <.001 | 1.21 | (1.11,1.32) | <.001 |
| Stroke | 125 | 2,990 | 1.20 | (1.01,1.42) | 0.04 | 1.10 | (0.93,1.29) | 0.26 | 1.00 | (0.88,1.14) | 0.997 |
Hazard ratios (HR) and 95% confidence intervals (CIs) are reported per standard deviation increase in sCD14 (316 ng/mL). P-values meeting the Bonferroni-corrected significance threshold of 0.013 are shown in bold.
*
Model 1: Adjusted for age and sex
†
Model 2: Model 1 + BMI, blood pressure medications, type 2 diabetes, SBP, total cholesterol, HDL cholesterol, current smoking
‡
Model 3: Model 2 + CRP