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. Author manuscript; available in PMC: 2021 Nov 20.
Published in final edited form as: Nat Immunol. 2021 May 20;22(6):711–722. doi: 10.1038/s41590-021-00928-y

Extended Data Fig. 7. NSP and H3ΔN Repression Primes the Chromatin to Facilitate Transcription Reprogramming During Cellular Differentiation.

Extended Data Fig. 7

(a-c) Increased chromatin accessibility at genes with important immune regulatory functions in ΔNSPs cells. ATAC-seq sequencing tracks of the loci encoding proinflammatory cytokines, immune regulators (a), differentiation markers (b), or differential genes upon differentiation (c) in ΔNSPs (blue) or control (purple) cells. X-axis, relative position to TSS in base pairs; y-axis, normalized read count in ΔNSPs (above zero) or control (below zero) cells; gray block, exon. H3ΔNThr22 genomic track in wild-type U937 cells is shown.