Figure 5.
DHHC21 loss-of-function attenuates septic injury-induced reduction in renal blood flow. (a,b) Representative recordings of RBF (a) and MAP (b) in different groups 24 h after septic injury. Images are representative of 8 mice. (c) The reduced RBF in WT mice upon septic injury is rescued in Zdhhc21dep/dep mice. n = 8 (d) No significant difference in MAP is observed between WT and Zdhhc21dep/dep mice upon septic injury. n = 8. Results represent mean ± SEM. *p ≤ 0.05 versus WT + Sham, #p ≤ 0.05 versus WT + CLP.