Table 1.

Cardiac structure- and function-related genes sequenced in the panel classified by disease associations.

HCM related	ACTC1, ACTN2, ANKRD1, CALR3, CAV3, CSRP3, JPH2, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYO6, MYOZ2, MYPN, NEXN, PDLIM3, PLN, PRKAG2, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TRIM63, VCL
ACM related	DES, DSC2, DSG2, DSP, JUP, LMNA, PKP2, PLN, RYR2, SCN5A, TGFB3, TMEM43
DCM related	ABCC9, ACTN2, ACTC1, ANKRD1, BAG3, CRYAB, CSRP3, DES, DMD, DSG2, EYA4, GATAD1, LAMA4, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYPN, NEXN, PLN, RBM20, SCN5A, SGCD, TAZ, TCAP, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, VCL, ZBTB17
LVNC related	DTNA, LDB3, LMNA, MIB1, MYBPC3, MYH7, PRDM16, TAZ, TNNT2, TPM1
Metabolic disorders and syndromes with cardiac diseases and congenital heart defects	ALMS1, BRAF, CBL, COX15, CRELD1, DNAJC19, DOLK, FXN, GAA, GLA, HFE, HRAS, JAG1, KRAS, LAMP2, MAP2K1, MAP2K2, NKX2-5, NODAL, NOTCH1, NRAS, PTPN11, RAF1, SCO2, SDHA, SHOC2, SMAD4, SOS1, TBX3, TBX20, TBX5, TTR, ZIC3
Arrhythmic disorders	AKAP9, ANK2, CACNA1C, CACNA2D1, CACNB2, CALM1, CASQ2, CAV3, DPP6, GJA5, GPD1L, HCN4, KCNA5, KCND3, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ5, KCNJ8, KCNQ1, NPPA, RANGRF, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SNTA1, TRDN, TRPM4
Dyslipidemia	ABCG5, ABCG8, APOA5, APOB, APOC2, APOE, CETP, GPIHBP1, LDLR, LDLRAP1, LMF1, LPL, PCSK9, SREBF2
Aortopathies/EDS	ACTA2, COL3A1, COL5A1, COL5A2, EFEMP2, ELN, FBN1, FBN2, MYH11, MYLK, SLC2A10, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2
Muscular dystrophies/myopathies	ACTA1, BAG3, EMD, FHL1, FKRP, FKTN, LAMA2, RYR1, SEPN1, SGCB, SGCD, SGCG, SLC25A4, TMEM43
Other	APOA4, CBS, CREB3L3, CTF1, FHL2, GCKR, HADHA, HSPB8, ILK, KLF10, LTBP2, MURC, PRKAR1A, SALL4, TXNRD2, ZHX3

Genes in bold had potentially disease related variants in sudden cardiac death victims.

ACM arrhythmogenic cardiomyopathy, DCM dilated cardiomyopathy, EDS Ehlers-Danlos syndrome, HCM hypertrophic cardiomyopathy, LVNC left ventricular non-compaction cardiomyopathy.