Table 1.
Clinical characteristics of patients whose salivary gland biopsies were analyzed by RNAseq.
| Clinical classification | Patient | Age | Gender | Anti-SSA/Ro | Anti-SSB/La | ANA | Schirmer test | Saliva secretion (ml/15 min) | Dry mouth | Dry eyes | FS | Germinal Centers (CD21+) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-SS | Non-SS1 | 45 | F | − | − | − | + | 0.5 | + | + | − | − |
| Non-SS2 | 53 | F | − | − | − | − | 0.0 | + | + | − | − | |
| Non-SS3 | 51 | F | − | − | − | − | 0.0 | + | + | − | − | |
| Non-SS4 | 51 | F | − | − | − | + | 3.2 | + | + | − | − | |
| Non-SS5 | 34 | F | − | − | − | + | 1.0 | + | + | − | − | |
| Non-SS6 | 59 | F | − | − | − | + | 2.6 | + | + | − | − | |
| Non-SS7 | 32 | F | − | − | − | + | 4.0 | − | + | − | − | |
| Non-SS8 | 40 | F | − | − | − | + | 2.1 | + | + | − | − | |
| SS | SS1 | 62 | F | + | + | + | − | 1.7 | + | + | 1 | − |
| SS2 | 74 | F | − | − | − | + | 0.9 | + | + | 2 | + | |
| SS3 | 51 | F | − | − | − | + | 1.7 | + | + | 1 | − | |
| SS4 | 56 | F | − | − | − | + | 2.8 | + | + | 1 | − | |
| SS5 | 53 | F | − | − | − | + | 1.8 | + | + | 2 | + | |
| SS6 | 79 | F | + | + | + | NT | 1.0 | + | + | 4 | + | |
| SS7 | 55 | F | − | − | − | + | 4.4 | + | + | 2 | + | |
| SS8 | 52 | F | + | − | + | + | 6.6 | − | + | 3 | + |
ANA antinuclear antibodies; Saliva secretion (unstimulated flow); normal flow > 1.5 ml/15 min; Schirmer test positive when reduced tear secretion (objective test); Dry mouth and dry eyes, subjective symptoms from the patient, FS Focus Score, NT not determined. Germinal center-like structures may result from the deregulated proliferation and infiltration of lymphocytes in glandular tissue.